Injectable rabies vaccine composition and method for preparing s

Details Injectable rabies vaccine composition and method for preparing s Injectable rabies vaccine composition and method for preparing s

1979-09-21

1981-02-24

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

435235, 435238, A61K 39205

Patent

active

042527929

ABSTRACT:
A rabies vaccine composition is disclosed which comprises a sterilized suspension of proteineous suckling mice or rat brain particles of injectable particle size laden with an amount of inactivated rabies virus which is equivalent to a virus titer of from at least about 10.sup.5 to about 10.sup.7 MLD.sub.50 per 0.01 milliliter thereof at a brain tissue concentration of from about 3 to about 6% by weight, in an aqueous buffer solution having a pH of between about 7.5 and about 8.4, and comprising an amount, dissolved therein, of between 0.03 and 0.08 moles per liter of a buffer composition comprising a mixture of an organic base of the formula ##STR1## wherein R.sub.1 and R.sub.2 each are hydrogen or CH.sub.2 CH.sub.2 OH and an acid addition salt thereof, preferably a mixture of tris (hydroxymethyl)amino methane and its hydrochloride. The vaccine composition exhibits a high potency and its pH value remains stable over a prolonged period of time.

REFERENCES:
Swim et al., Science 122:466 (1955), Nonbicarbonate Buffers in Cell Culture Media. _
Eagle Science 174(4008):500-3 (1971), Buffer Combinations for Mammalian Cell Cultures. _
Fuenzalida, Bull W. H. O. 46:561-3 (1972), Human Pre-Exposure Rabies Immunization with Suckling Mouse Brain Vaccine. _
Fuenzalida et al., Bull. W. H. O. 30:431-6 (1964), Antirabies Antibody Response in Man to Vaccine Made From Infected Suckling Mouse Brains. _
W.H.O. Monograph Series No. 23, Lab. Techn. in Rabies, 3rd Ed. 367 pp. (1973): 213-200. _
Fields et al., Vet. Med. Small Anim. Clin. 71(1): 37-40 Jan. 1976, Suckling Mouse Brain Rabies Vaccine: Duration of Immunity in Dogs. _
Waterson, Recent Advances in Clinical Virology No. 1 Turner An Assessment of the Current Position of Rabies Vaccination in Man, pp. 79-92, (1977). _
Fuenzalida et al., Instituto Bacteriol. de Chile Boletin, vol. 8:3-10 (1955), Rabies Vaccine Prepared from the Brains of Infected Suckling Mice. _

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