Method of making asymmetric de ring intermediates for the synthe

Details Method of making asymmetric de ring intermediates for the synthe Method of making asymmetric de ring intermediates for the synthe

1993-11-30

1995-03-07

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D491056, C07D49106

Patent

active

053959396

ABSTRACT:
Methods of making asymmetric DE ring intermediates for the synthesis of camptothecin and camptothecin analogs employ a dioxane intermediate as the immediate precursor to the DE ring intermediate. Novel intermediates are also disclosed.

REFERENCES:
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patent: 4477671 (1984-10-01), Cue
patent: 4610990 (1986-09-01), Esanu
patent: 4713458 (1987-12-01), Frazier
patent: 5162532 (1992-11-01), Comins et al.
patent: 5212317 (1993-05-01), Comins et al.
patent: 5342947 (1994-08-01), Lackey et al.
Daniel L. Comins, et al., A 10-Step Asymetric Synthesis of (S)-Camptothecin, Journal of the American Chemical Society, pp. 10971-10972, 1992.

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