Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-05-19
1998-03-10
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
5303873, C07K 14705, C07K 1900
Patent
active
057262900
ABSTRACT:
Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.
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Bodary Sarah C.
Gorman Cornelia M.
McLean John W.
Napier Mary A.
Brown Karen E.
Conley Deirdre L.
Genentech Inc.
Lee Wendy M.
Ulm John
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