Substituted keto and alkoxy carbonyl esters of 16-substituted PG

Details Substituted keto and alkoxy carbonyl esters of 16-substituted PG Substituted keto and alkoxy carbonyl esters of 16-substituted PG

1975-11-21

1977-03-08

Gerstl, Robert

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260468D, 260471R, 260473R, 260476R, C07C17700

Patent

active

040112497

ABSTRACT:
Substituted phenyl and naphthyl esters of PGE.sub.2 analogs, including the 16-alkyl, 16-fluoro, 16-phenoxy, and phenyl-substituted analogs, and their 15-epimers, and their racemic forms, and processes for producing them are disclosed. The products are useful for the same pharmacological and medical purposes as these PGE.sub.2 analogs, and are also useful as a means for obtaining highly purified 16,16-dimethyl-PGE.sub.2, 16-phenoxy-17,18,19,20-tetranor-PGE.sub.2, and 17-phenyl-18,19,20-trinor-PGE.sub.2.

REFERENCES:
patent: 3839062 (1975-07-01), Morozowich

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