Method for diagnosing rheumatoid arthritis

Details Method for diagnosing rheumatoid arthritis Method for diagnosing rheumatoid arthritis

1993-02-19

1995-03-07

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 5, 435 6, 435 79, 435 792, 435 21, 436506, 436513, 436543, C12Q 100, C12Q 168, G01N 3353, G01N 33564

Patent

active

053957539

ABSTRACT:
A method is described for diagnosing rheumatoid arthritis by providing a recombinant IgM-specific rheumatoid arthritis-associated antigen and detecting antibodies against the antigen in patient sera. Preliminary steps of making a cDNA library from polyadenylated RNA purified from human cells, selecting recombinants that express the antigen, recloning cDNA containing the antigen gene in a high level expression vector, expressing the antigen in transformed cells, and purifying the antigen are also described.

REFERENCES:
Kemp, M. et al.; Biol. Abstracts 81:63056 (1986).
Habets, W. J. A. et al.; Clin. Exp. Immunol. 76:172 (1989)
Kunakorn, M. et al.; J. Clin. Microbiol. 28:1249-1253 (1990).
Jirik, F. R. et al.; Proc. Natl. Acad. Sci. USA 83:2195-2199 (1986).
Artandi et al., J. Immunol. 146(2):603-610 (1991).
Halpert et al., Am. J. Clin. Pathol. 74:776-784 (1980).
Dillon et al. (EDS.), Recombinant DNA Methodology, John Wiley & Sons, New York, N.Y., 1985, pp. 83-88.

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