Process for the synthesis of 9-(.beta.-D-arabinofuranosyl)adenin

Details Process for the synthesis of 9-(.beta.-D-arabinofuranosyl)adenin Process for the synthesis of 9-(.beta.-D-arabinofuranosyl)adenin

1994-09-21

1996-04-09

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2613, C07H 19167, C07H 100

Patent

active

055063527

ABSTRACT:
An improved process for the preparation of 9-(.beta.-D-arabinofuranosyl)adenine, 5'-phosphate, is described where dried 9-(.beta.-D-arabinofuranosyl)adenine is reacted with triethyl phosphate and phosphorous oxychloride in dichloromethane and the reaction mixture hydrolyzed and excess hydrogen chloride removed with propylene oxide as the acid scavenger. This process gives a yield of about 70-85%, which is nearly double the yields of the prior art.

REFERENCES:
patent: 3413282 (1972-11-01), Yoshikawa et al.
patent: 3703507 (1972-11-01), Haskell et al.
patent: 3943000 (1976-03-01), Ferrar
patent: 4123609 (1978-10-01), Behnke et al.
patent: 4767873 (1988-08-01), Katz et al.
patent: 4814407 (1989-03-01), Canova et al.

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