Process for preparing 2-methyl-3,5-dialkylpyridines by dealkylat

Details Process for preparing 2-methyl-3,5-dialkylpyridines by dealkylat Process for preparing 2-methyl-3,5-dialkylpyridines by dealkylat

1990-08-10

1991-10-29

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546251, C07D213127, C07D21316

Patent

active

050618059

ABSTRACT:
A process for dealkylating the 2-position on a trisubstituted pyridine derivative having the formula ##STR1## where R.sub.1 is a straight chain alkyl group from about C.sub.2 -C.sub.5 and where R.sub.2 and R.sub.3 are alkyl, aryl or aralkyl groups up to about C.sub.10, comprising the step of reacting said pyridine derivative at reflux with excess sulfur. Of particular note is the preparation of 2,3,5-trimethylpyridine including the initial preparation of its 2-ethyl precursor by the Chichibabin reaction of propionaldehyde and ammonia.

REFERENCES:
patent: 4255431 (1981-03-01), Junggren et al.
patent: 4337257 (1982-06-01), Junggren et al.
patent: 4658032 (1987-04-01), Yamaji
C. R. Adams & J. Falbe, Brennstoff Chem., 47, 184-187 (1966).

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