Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Tripeptides – e.g. – tripeptide thyroliberin – etc.
Patent
1989-06-08
1991-10-29
Ivy, C. Warren
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Tripeptides, e.g., tripeptide thyroliberin , etc.
530323, 564158, 564159, 514885, C07C23700, A61K 3702
Patent
active
050617877
ABSTRACT:
The present invention relates to novel spergualin-related compounds represented by the general formula [I]: ##STR1## wherein X is --(CH.sub.2).sub.1.about.5 or ##STR2## Y is a hydrogen atom or a residue obtained by removing a hydroxyl group from the carboxyl group of an amino acid or a peptide; m is 0, 1 or 2 and n is 1 or 2, with the proviso that Y is not a hydrogen atom when n is 2 and m is 0.
This compounds are stable and exhibit a high immunosuppressive activity.
REFERENCES:
patent: 4518532 (1985-05-01), Umezawa et al.
patent: 4525299 (1985-06-01), Umezawa et al.
Peptide Chemistry, "Spergualin Analogues: Syntheses and Their Biological Activities", 1987, pp. 671-674.
Nishizawa et al, Jol. of Antibiotics, vol. 41, No. 11, 1988, pp. 1629-1643 "Synthesis and Biological Activity of Spergualin Analogues I".
Nemoto Kyuichi
Saino Tetsushi
Tomiyoshi Tsugio
Umeda Yoshihisa
Covington Raymond
Ivy C. Warren
Nippon Kayaku Kabushiki Kaisha
Takara Shuzo Kabushiki Kaisha
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