Cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids, a proc

Details Cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids, a proc Cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids, a proc

1989-01-12

1991-10-29

Ceperley, Mary E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548452, A61K 3140, C07D20902

Patent

active

050617222

ABSTRACT:
Compounds of the formula I ##STR1## in which the carboxyl group on carbon atom 3 is orientated in the endo-position relative to the bicyclic ring system of cis-configuration, and in which R.sup.1 denotes hydrogen, allyl, vinyl or a side-chain of a naturally occurring .alpha.-aminoacid, which may be protected, R.sup.2 denotes hydrogen, alkyl, alkenyl or aralkyl, Y denotes hydrogen or hydroxyl and 2 denotes hydrogen, or Y and Z together denote oxygen, and X denotes alkyl, alkenyl or cycloalkyl, or aryl which is optionally mono-, di- or tri-substituted by alkyl, alkoxy, hydroxyl, halogen, nitro, amino, alkylamino, dialkylamino or methylenedioxy, or denotes indol-3-yl, a process for their preparation, agents containing these compounds and their use.

REFERENCES:
patent: 4344949 (1982-11-01), Hoefle et al.
patent: 4350704 (1982-09-01), Hoefle et al.
patent: 4404206 (1983-09-01), Vincent et al.
patent: 4468396 (1984-08-01), Magatti
patent: 4490386 (1984-12-01), Seamans et al.
patent: 4525301 (1985-06-01), Henning et al.
patent: 4558064 (1985-12-01), Teetz et al.
patent: 4558065 (1985-12-01), Urbach et al.
patent: 4559340 (1985-12-01), Neustadt et al.
patent: 4562202 (1985-12-01), Urbach et al.
patent: 4591598 (1986-05-01), Urbach et al.
patent: 4614805 (1986-09-01), Urbach et al.
patent: 4620012 (1986-10-01), Henning et al.
patent: 4659838 (1987-04-01), Lerch
patent: 4668796 (1987-05-01), Geiger et al.
patent: 4668797 (1987-05-01), Urbach et al.
patent: 4684662 (1987-08-01), Henning et al.
patent: 4691022 (1987-09-01), Henning et al.
patent: 4714708 (1987-12-01), Urbach et al.
patent: 4727160 (1988-02-01), Teetz et al.
patent: 4808573 (1989-02-01), Gold et al.
patent: 4818749 (1989-04-01), Gold et al.
patent: 4822894 (1989-04-01), Geiger et al.
patent: 4831157 (1989-05-01), Gold et al.
Farkas, E., "Preparation of 3-Dehydroreserpic Acid Lactone and Its Conversion To Reserpic Acid Lactone", J. Org. Chem., 22, 1261-1263 (1957).
Taylor, E. et al., "Pteridines. XXXII. 2-Amino-3-Cyano-5-Chloromethylpyrazine 1-Oxide and Its Conversion to 6-Alkenyl-Substituted Pteridines", J. Org., 38 (16), 2817-2821 (1973).
Taylor, E. et al., "a Novel `Ring-Switching` Amination: Conversion of 4-Amino-5-Cyanopyrimidne to 4, 6-Diamino-5-Cyanopyrimidne", Heterocycles, 25, 343-345 (1987).
Mitzlaff, M. et al., "Anodic Alkoxylation of N-Acylazacycloalkanes", Liebig's Ann. Chem., 1713-1733 (1978).
Leonard et al., J. Am. Chem. Soc., 77, 439 (1955).
Leonard et al., J. Am. Chem. Soc., 78, 3457 (1956).
Leonard et al., J. Am. Chem. Soc., 78, 3463 (1956).
Leonard et al., J. Am. Chem. Soc., 81, 5627 (1959).
Koelsch et al., J. Org. Chem., 26, 1104 (1961).
Griot et al., Helv. Chim. Acta, 42, 121 (1959).
Bonnet et al., J. Chem. Soc., 2087 (1959).
Battersby et al., J. Chem. Soc., 4333 (1958).
Rosenblatt et al., The Chemistry of Functional Groups. Supplement F: The Chemistry of Amino, Nitroso and Nitro Compounds and Their Derivatives. Part II, S. Patai, ed., Wiley & Sons, New York, 1982, pp. 1100-1104.
L. W. Haynes, Enamines, A. G. Cook, ed., Marcel Decker, Inc., 1969, pp. 68-79, 261-269, 413.
Fieser & Fieser, Reagents for Organic Synthesis, vol. 1, pp. 644-651 (1967).
Boehme et al., Iminium Salts In Organic Chemistry, Part I (E. C. Taylor, ed.), Wiley & Sons, New York, 1976, p. 143.
S. Dayagi et al., The Chemistry of Functional Groups. The Chemistry of the Carbon-Nitrogen Double Bond, S. Patai, ed., Wiley & Sons, New York, 1970, p. 119.
W. Greenlee et al., J. Med. Chem., 28, 434-442 (1985).
K. Ogawa et al., J. Chem. Soc., Perkin Trans. I, 3031-3035 (1982).
R. Bacon and D. Stewart, J. Chem. Soc. (C), 1384-1387 (1966).
R. Bacon et al., J. Chem. Soc. (C), 1388-1389 (1966).
Patchett et al., Nature, 288, 280-283 (1980).
Booth et al., Chemistry and Industry, 466-467 (1956).
Booth et al., J. Chem. Soc., Part I, 1050-1054 (1959).
Murakoshi et al., "Chemical Abstracts", 61, 9465(e)(1964).
Cushman et al., Fed. Proc., 38 (13), 2778-2782 (1979).
Houben-Weyl, Methoden der Organischen Chemie, 7(2b), 1403-1404 (1976).
Katritskaya, Dzh. Lagorskaya Khimia Geterosikl. Soedin., Moskow, 1963, pp. 155-158.
Anderson, Jr. et al., J. Org. Chem., 43(1), 54-57 (1978).
Bertho et al., Chemische Berichte, 92 (7), 2218-2235 (1959).

Affiliated with

Also associated with

Rating

Cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids, a proc does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids, a proc, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cis, endo-2-azabicyclo-[3.3.0]-octane-3-carboxylic acids, a proc will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1400873