Method of preparing aryl-(1-phthalimido)-alkyl ketones

Details Method of preparing aryl-(1-phthalimido)-alkyl ketones Method of preparing aryl-(1-phthalimido)-alkyl ketones

1988-08-22

1990-07-31

Ceperley, Mary E.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548455, 548461, 548479, C07D40506, C07D20948

Patent

active

049451685

ABSTRACT:
Aryl-(1-phthalimido)-alkyl ketones of the general formula ##STR1## are prepared by reacting a suitable aromatic compound with ##STR2## at least one hydrogen atom on the aromatic nucleus in an inert solvent and in the presence of iron-(III)-chloride with an N-phthaloyl-2-amino carboxylic acid chloride of the general formula ##STR3## They can be converted into corresponding 2-phenethanolamines or 2-phenethylamines by reduction of the keto group.

REFERENCES:
patent: 3308135 (1967-03-01), Jansen et al.
D. McClure et al., J. Organic Chemistry, vol. 48, No. 16, p. 2675 (1983).
L. Buckley, III et al., J. Am. Chem. Soc., vol. 103, p. 6157 (1981).
A. Hildesheimer, Ber. Dtsch. Chem. Ges., vol. 43, p. 2796 (1910).
S. Gabriel, Ber. Dtsch. Chem. Ges., vol. 44, p. 57 (1911).
R. Morrison et al., Organic Chemistry (second edition), p. 622 (1967), Allyn and Bacon, Inc., Boston.
Kirk-Othmer, Encyclopedia of Chemical Technology (second edition), vol. 10, p. 159 (1966), John Wiley and Sons, Inc.

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