Preparation of N-hydroxypyrazoles

Details Preparation of N-hydroxypyrazoles Preparation of N-hydroxypyrazoles

1989-06-16

1990-07-31

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548376, C07D23112

Patent

active

049451677

ABSTRACT:
N-hydroxypyrazoles of the general formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 may be identical or different and are each hydrogen or halogen, are prepared by a process in which a pyrazole of the general formula II ##STR2## where R.sup.1, R.sup.2 and R.sup.3 have the meanings stated for formula I, is reacted with an aliphatic or aromatic peroxocarboxylic acid, preferably in the presence of from 0 to 15 moles of an alkali metal hydroxide, alkaline earth metal hydroxide, alkali meteal carbonate or alkaline earth metal carbonate in such a way that the reaction temperature is from -5.degree. C. to 60.degree.C.
The reaction can be carried out in water as a solvent or in a 2-phase system consisting of water and an inert organic solvent which is poorly miscible with water, in the presence or absence of a suitable phase transfer catalyst. The peroxocarboxylic acid can be prepared in the reaction mixture before the reaction from H.sub.2 O.sub.2 and an acyl halide or a carboxylic anhydride or can be used in the form of an alkali metal salt or alkaline earth metal salt.

REFERENCES:
patent: 4350819 (1982-09-01), Rieber et al.

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