Process for producing substituted pyrroles

Details Process for producing substituted pyrroles Process for producing substituted pyrroles

1982-12-09

1984-05-29

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548539, 548527, C07D207333

Patent

active

044516584

ABSTRACT:
Alkyl 1,4-dialkylpyrrole-2-alkanoates are prepared by the selective decarboxylation of a 1,4-dialkyl-3-carboxypyrrole-2-alkanoic acid or an alkyl ester or alkali metal salt thereof under moderate conditions with a mixture of a strong mineral acid, an alkanol, and water. The products are useful for the preparation of anti-inflammatory agents.

REFERENCES:
patent: 3752826 (1973-08-01), Carson
patent: 3865840 (1975-02-01), Carson
patent: 3952012 (1976-04-01), Carson
Jones et al. "The Chemistry of Pyrroles" Academic Press 1977, pp. 328-331.

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