Substituted 1-(oxopyrrolidinylalkanoyl)-piperazines useful as no

Details Substituted 1-(oxopyrrolidinylalkanoyl)-piperazines useful as no Substituted 1-(oxopyrrolidinylalkanoyl)-piperazines useful as no

1989-06-19

1990-07-31

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544372, A61K 31495, C07D40312, C07D40314

Patent

active

049450921

ABSTRACT:
Substituted pyrrolidin-2-ones of the formula ##STR1## wherein R.sub.1 represents a phenyl or naphthyl radical that is unsubstituted or substituted by lower alkyl, lower alkloxy, halogen and/or trifluoromethyl, X.sub.1 represents lower alkylidene, X.sub.2 represents methylene, ethylene or oxoethylene and R.sub.2 represents hydrogen, lower alkyl or a radical of the formula ##STR2## wherein X.sub.4 represents lower alkylidene and R.sub.3 represents hydrogen or a phenyl or a phenyl naphthyl radical that is unsubstituted by lower alkyl, lower alkoxy, halogen and/or trifluoromethyl, and their pharmaceutically acceptable salts, have nootropic properties and can be used as nootropic active ingredients in medicaments. They are prepared, for example, by condensing with one another compounds of the formulae ##STR3## wherein Z.sub.1 represents a group of the formula --X.sub.1 --(.dbd.O)--Z.sub.3 (IIa) and Z.sub.2 represents hydrogen, or Z.sub.1 represents hydrogen and Z.sub.2 represents a group of the formula --C(.dbd.O) --X.sub.1 --Z.sub.4 (IIIa), wherein each of Z.sub.3 and Z.sub.4 represents a removable radical and R.sub.2 ' represnts a radical R.sub.2 or amino-protecting group, or their salts, and removing an amino-protecting R.sub.2 ' which may be present.

REFERENCES:
patent: 3459738 (1969-08-01), Morren
patent: 4144246 (1979-03-01), L'Italien
CA 95:24693r (1981).

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