Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1982-06-21
1984-05-29
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, 260112R, A61K 3700, C07C10352, C07G 700
Patent
active
044514565
ABSTRACT:
An antitumor antibacterial complex referred to as BBM-928 is described which is produced by microbiological fermentation under controlled conditions using a species of actinomycetes. The bioactive components of the complex have pronounced antitumor activity and are moderately to weakly active against gram-positive and acid fast bacteria but practically inactive against gram-negative bacteria and fungi. Based on median survival time, the component designated BBM-928A is substantially more active than mitomycin C by a factor of 10 to 300 fold against intraperitoneally implanted mouse tumors.
REFERENCES:
patent: 4360458 (1982-11-01), Koshiyama et al.
Koshiyama Hideo
Ohkuma Hiroaki
Sakai Fumihide
Bristol-Myers Company
Carnahan Robert E.
Phillips Delbert R.
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