Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahyd

Details Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahyd Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahyd

1983-03-18

1985-12-03

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 44, 546 18, 546 74, 564139, C07D21720

Patent

active

045567123

ABSTRACT:
In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids.

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Beyerman et al., Synthesis of Racemic and Optically Active Codiene and Morphine. . ." J. Royal Neth. Chem. Soc. 97, pp. 127-130, (1978).
Brossi et al., "Synthesis . . . Isoquinoline Series . . . ," Helv. Chim. Acta 44: 1558-1565, (1961).

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