Polymers for delivering nitric oxide in vivo

Details Polymers for delivering nitric oxide in vivo Polymers for delivering nitric oxide in vivo

1996-08-02

1998-06-23

Kulkosky, Peter F.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

At least one aryl ring which is part of a fused or bridged...

536 46, 536103, 5361231, 525 543, A61K 31785, A61K 31095, A61K 31795

Patent

active

057706450

ABSTRACT:
Disclosed are novel polymers derivatized with at least one --NO.sub.X group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

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Stamler, J. S., et al. "S-Nitrosylation of Proteins with Nitric Oxide: Synthesis and Characterization of Biologically Active Compounds," Proc. Natl. Acad. Sci USA 89:444-448 (Jan. 1992).
Bauer, J. A. and Ho-Leung Fung, "Chemical Stabilization of a Vasoactive S-Nitrosothiol with Cyclodextrins without Loss of pharmacologic Activity," Pharmaceutical Research, 8 (10):1329-1333 (1991).
Langford, E. J., et al., "Inhibition of Platelet Activity by S-Nitrosoglutathione During Coronary Angioplastry," The Lancet, 344:1458-1460 (1994).

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