Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors

Details Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors

1994-05-09

1996-04-09

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514445, 549 62, 549 65, C07D33332, C07D33334, A61K 3138, A61K 31385

Patent

active

055062610

ABSTRACT:
Compounds of the structure ##STR1## wherein Z is selected from optionally substituted thienyl, thiazolyl, oxazolyl and furyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

REFERENCES:
patent: 5169854 (1992-12-01), Brooks et al.
patent: 5288751 (1994-02-01), Brooks et al.

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