Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1998-06-23
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514324, 514422, 514428, 514444, 514448, 514651, A61K 31445, A61K 3140, A61K 3138, A61K 31135
Patent
active
057706093
ABSTRACT:
A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I): ##STR1## wherein Z is C.dbd.O or a covalent bond; Y is H or O(C.sub.1 -C.sub.4)alkyl, R.sup.1 and R.sup.2 are individually (C.sub.1 -C.sub.4)alkyl or together with N are a saturated heterocyclic group, R.sup.3 is ethyl or chloroethyl, R.sup.4 is H or together with R.sup.3 is --CH.sub.2 --CH.sub.2 -- or --S--, R.sup.5 is I, O(C.sub.1 -C.sub.4)alkyl or H and R.sup.6 is I, O(C.sub.1 -C.sub.4)alkyl or H with the proviso that when R.sup.4, R.sup.5, and R.sup.6 are H, R.sup.3 is not ethyl; or a pharmaceutically acceptable salt thereof, effective to activate or stimulate production of TGF-beta to treat and/or prevent conditions such as atherosclerosis, thrombosis, myocardial infarction, and stroke is provided. Useful compounds include idoxifene and salts thereof. Further provided is a method for identifying a compound that is a TGF-beta activator or production stimulator is provided. Another embodiment of the invention is an assay or kit to determine TGF-beta in vitro. Also provided is a therapeutic method comprising inhibiting smooth muscle cell proliferation associated with procedural vascular trauma employing the administration of tamoxifen or structural analogs thereof, including compounds of formula (I).
REFERENCES:
patent: Re32944 (1989-06-01), Harita et al.
patent: 2914563 (1959-11-01), Allen et al.
patent: 3010965 (1961-11-01), Elpern
patent: 3168565 (1965-02-01), Palopoli et al.
patent: 3288806 (1966-11-01), DeWald et al.
patent: 3634517 (1972-01-01), Palopoli et al.
patent: 3940422 (1976-02-01), Harita et al.
patent: 4070484 (1978-01-01), Harita et al.
patent: 4093709 (1978-06-01), Choi et al.
patent: 4133814 (1979-01-01), Jones et al.
patent: 4230862 (1980-10-01), Suarez
patent: 4235988 (1980-11-01), Fildes et al.
patent: 4307111 (1981-12-01), Crawley
patent: 4323707 (1982-04-01), Suarez
patent: 4380635 (1983-04-01), Peters
patent: 4418068 (1983-11-01), Jones
patent: 4442119 (1984-04-01), Magarian et al.
patent: 4512762 (1985-04-01), Spears
patent: 4536516 (1985-08-01), Harper et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4696949 (1987-09-01), Toivola, et al.
patent: 4824436 (1989-04-01), Wolinsky
patent: 4826672 (1989-05-01), Milius et al.
patent: 4835002 (1989-05-01), Wolf et al.
patent: 4839155 (1989-06-01), McCague
patent: 4859585 (1989-08-01), Sonnenschein et al.
patent: 4879315 (1989-11-01), Magarian et al.
patent: 4929602 (1990-05-01), Harker et al.
patent: 4962091 (1990-10-01), Eppstein et al.
patent: 4968350 (1990-11-01), Bindschaedler et al.
patent: 4973755 (1990-11-01), Grafe et al.
patent: 4990538 (1991-02-01), Harris et al.
patent: 4996225 (1991-02-01), Toivola et al.
patent: 4997652 (1991-03-01), Wong
patent: 5008279 (1991-04-01), Franckowiak et al.
patent: 5015666 (1991-05-01), Magarian et al.
patent: 5026537 (1991-06-01), Dadonna et al.
patent: 5032679 (1991-07-01), Brandley et al.
patent: 5043335 (1991-08-01), Kleinschroth
patent: 5047431 (1991-09-01), Schickaneder et al.
patent: 5049132 (1991-09-01), Shaffer et al.
patent: 5053033 (1991-10-01), Clarke
patent: 5059166 (1991-10-01), Fischell et al.
patent: 5066789 (1991-11-01), Srinivasan et al.
patent: 5075321 (1991-12-01), Schreiber
patent: 5098903 (1992-03-01), Magarian et al.
patent: 5102402 (1992-04-01), Dror et al.
patent: 5112305 (1992-05-01), Barath et al.
patent: 5114719 (1992-05-01), Sabel et al.
patent: 5116864 (1992-05-01), March et al.
patent: 5120535 (1992-06-01), Marquardt et al.
patent: 5140012 (1992-08-01), McGovern et al.
patent: 5166143 (1992-11-01), Ondetti et al.
patent: 5171217 (1992-12-01), March et al.
patent: 5176617 (1993-01-01), Fischell et al.
patent: 5180366 (1993-01-01), Woods et al.
patent: 5185260 (1993-02-01), Crissman et al.
patent: 5189046 (1993-02-01), Burch et al.
patent: 5189212 (1993-02-01), Ruenitz
patent: 5192525 (1993-03-01), Yang et al.
patent: 5199939 (1993-04-01), Dake et al.
patent: 5208019 (1993-05-01), Hansson et al.
patent: 5213576 (1993-05-01), Abiuso et al.
patent: 5213580 (1993-05-01), Stepian et al.
patent: 5216126 (1993-06-01), Cox et al.
patent: 5219548 (1993-06-01), Yang et al.
patent: 5221620 (1993-06-01), Purchio et al.
patent: 5226430 (1993-07-01), Spears et al.
patent: 5229495 (1993-07-01), Ichijo et al.
patent: 5238714 (1993-08-01), Wallace et al.
patent: 5238950 (1993-08-01), Clader et al.
patent: 5242397 (1993-09-01), Barath et al.
patent: 5248764 (1993-09-01), Flanagan et al.
patent: 5254594 (1993-10-01), Niikura et al.
patent: 5268358 (1993-12-01), Fretto
patent: 5270047 (1993-12-01), Kaufman et al.
patent: 5280016 (1994-01-01), Conrad et al.
patent: 5280109 (1994-01-01), Miyazono et al.
patent: 5283257 (1994-02-01), Gregory et al.
patent: 5284763 (1994-02-01), Derynk et al.
patent: 5284869 (1994-02-01), Bisaccia et al.
patent: 5288711 (1994-02-01), Mitchell et al.
patent: 5296492 (1994-03-01), Shiozawa et al.
patent: 5304325 (1994-04-01), Kaufman et al.
patent: 5304541 (1994-04-01), Purchio et al.
patent: 5308622 (1994-05-01), Casscells et al.
patent: 5308862 (1994-05-01), Ohlstein
patent: 5314679 (1994-05-01), Lewis et al.
patent: 5316766 (1994-05-01), Baldus et al.
patent: 5324736 (1994-06-01), Magarian et al.
patent: 5326757 (1994-07-01), Demopoulos
patent: 5328471 (1994-07-01), Slepian
patent: 5332584 (1994-07-01), Scher et al.
patent: 5340925 (1994-08-01), Lioubin et al.
patent: 5346702 (1994-09-01), Na et al.
patent: 5346993 (1994-09-01), Miyazono et al.
patent: 5354562 (1994-10-01), Platz et al.
patent: 5354774 (1994-10-01), Deckelbaum et al.
patent: 5354801 (1994-10-01), O'Toole et al.
patent: 5356713 (1994-10-01), Charmot et al.
patent: 5362424 (1994-11-01), Lee et al.
patent: 5364632 (1994-11-01), Benita et al.
patent: 5380716 (1995-01-01), Conrad et al.
patent: 5384332 (1995-01-01), Fontana
patent: 5385935 (1995-01-01), Tamari et al.
patent: 5389670 (1995-02-01), Fontana
patent: 5391557 (1995-02-01), Cullinan et al.
patent: 5393763 (1995-02-01), Black et al.
patent: 5393772 (1995-02-01), Yue et al.
patent: 5393785 (1995-02-01), Labrie et al.
patent: 5395842 (1995-03-01), Labrie et al.
patent: 5418252 (1995-05-01), Williams
patent: 5423885 (1995-06-01), Williams
patent: 5424331 (1995-06-01), Shlyan-kevich
patent: 5426123 (1995-06-01), Fontana
patent: 5429634 (1995-07-01), Narciso, Jr.
patent: 5434166 (1995-07-01), Glasebrook
patent: 5436243 (1995-07-01), Sachs et al.
patent: 5439923 (1995-08-01), Cullinan
patent: 5439931 (1995-08-01), Sales
patent: 5441947 (1995-08-01), Dodge et al.
patent: 5441964 (1995-08-01), Bryant et al.
patent: 5441965 (1995-08-01), Sall et al.
patent: 5441966 (1995-08-01), Dodge
patent: 5441986 (1995-08-01), Thompson
patent: 5444164 (1995-08-01), Purchio et al.
patent: 5445941 (1995-08-01), Yang
patent: 5446053 (1995-08-01), Keohane
patent: 5447941 (1995-09-01), Zuckerman
patent: 5453442 (1995-09-01), Bryant et al.
patent: 5457113 (1995-10-01), Cullinan et al.
patent: 5457117 (1995-10-01), Black et al.
patent: 5462937 (1995-10-01), Cullinan et al.
patent: 5466810 (1995-11-01), Godfrey
patent: 5470883 (1995-11-01), Stromberg
patent: 5472985 (1995-12-01), Grainger et al.
patent: 5480888 (1996-01-01), Kodama et al.
patent: 5480904 (1996-01-01), Bryant et al.
patent: 5482949 (1996-01-01), Black et al.
patent: 5482950 (1996-01-01), Bryant et al.
patent: 5484795 (1996-01-01), Bryant et al.
patent: 5484796 (1996-01-01), Bryant et al.
patent: 5484798 (1996-01-01), Bryant et al.
patent: 5484808 (1996-01-01), Grinnell
patent: 5489587 (1996-02-01), Fontana
patent: 5491173 (1996-02-01), Toivola et al.
patent: 5492921 (1996-02-01), Bryant et al.
patent: 5492922 (1996-02-01), Palkowitz
patent: 5492926 (1996-02-01), Cullinan et al.
patent: 5492927 (1996-02-01), Glitter et al.
patent: 5496828 (1996-03-01), Cullinan
patent: 5498775 (1996-03-01), Novak et al.
patent: 5508292 (1996-04-01), Sall et al.
patent: 5510370 (1996-04-01), Hock et al.
patent: 5516807 (1996-05-01), Hupe et al.
patent: 5519042 (1996-05-01), Morris et al.
patent: 5521191 (1996-05-01), Greenwald
patent: 5527337 (1996-06-01), Stack et al
Grainger David J.
Kunz Lawrence L.
Metcalfe James C.
Schroff Robert W.
Weissberg Peter L.
Henley III Raymond
NeoRx Corporation
LandOfFree
Prevention and treatment of cardiovascular pathologies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Prevention and treatment of cardiovascular pathologies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prevention and treatment of cardiovascular pathologies will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1395058