Quinoline or quinazoline derivatives, their production and use

Details Quinoline or quinazoline derivatives, their production and use Quinoline or quinazoline derivatives, their production and use

1995-05-08

1998-06-23

Grumbling, Matthew V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 544284, 546173, A61K 3147, A61K 31505, C07D23972, C07D21558

Patent

active

057706026

ABSTRACT:
A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C--G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing unsaturated heterocyclic group which may be substituted for; each of rings A and B may have a substituent; n represents an integer from 1 to 4; k represents the integer 0 or 1, or a salt thereof, which serves well as an anti-inflammatory agent, particularly a therapeutic agent for arthritis.

REFERENCES:
patent: 5436247 (1995-07-01), Sohda
Synthesis, Georg Thieme Publishers, pp. 718-719, (1979).
Anzini et al., "Synthesis and 5HT-Receptors Affinity of Some 4-Phenylquinoline Derivatives", IL Farmaco, vol. 44(6):555-563, (1989).
Anzini et al., "Synthesis And Benzodiazepine Receptors Affinity Of 3-Carbethoxy-4-Phenylquinoline Derivtives", IL Farmaco, vol. 47(2):191-202, (1992).
Alhaider et al., "Design, Synthesis, and Pharmacological Activities Of 2-Substituted 4-Phenylquinolines As Potential Antidepressant Drugs", J. Med. Chem., vol. 28:1394-1398, (1985).

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