Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-11-15
1998-06-23
Jones, W. Gary
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 2, 524 12, 4241301, 530300, 530350, 426133, 426321, A61K 3800, C08J 8906, C07K 1300, A21D 400
Patent
active
057705712
ABSTRACT:
The present invention relates to compositions and methods for inhibiting the aging of amino-containing amino acid, peptides, proteins and biomolecules. Accordingly, a composition is disclosed which comprises an agent or compound capable of reacting with the glycosyl-amino moiety of the early glycosylation product (also known as the Amadori product or the Heyns product) formed by the reaction of glucose, or other reactive sugars, with an amino-containing peptide, protein or biomolecule, thus stabilizing this early glycosylation product, and preventing its further reaction to form open-chain, carbonyl-containing advanced glycosylation end products. Suitable agents may contain a reactive aldehyde group. A preferred agent is acetaldehyde. The method comprises contacting the target biomolecule with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
REFERENCES:
patent: 4665192 (1987-05-01), Cerami et al.
Hayase et al., J. Biol. Chem., 263, pp. 3758-3764 (1989).
Sell et al., "Structure Elucidation of a Senescence Cross-link from Human Extracellular Matrix", J. Biol. Chem., 264, pp. 21597-21602 (1989).
Al-Abed Yousef
Bucala Richard J.
Cerami Anthony
Ulrich Peter C.
Jones W. Gary
Rees Dianne
The Picower Institute for Medical Research
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