Human telomerase

Details Human telomerase Human telomerase

1996-07-08

1998-06-23

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

536 232, 4352523, 4353201, 530412, 530350, C12N 912, C12N 120, C12N 1500, C07H 2104

Patent

active

057704228

ABSTRACT:
The invention provides methods and compositions rel a human telomerase and related nucleic acids, including four distinct human telomerase subunit proteins called p140, p105, p48 and p43 having human telomerase-specific activity. The proteins may be produced recombinantly from transformed host cells from the disclosed telomerase encoding nucleic acids or purified from human cells. Also included are human telomerase RNA components, as well as specific, functional derivatives thereof. The invention provides isolated telomerase hybridization probes and primers capable of specifically hybridizing with the disclosed telomerase gene, telomerase-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

REFERENCES:
patent: 5583016 (1996-12-01), Villeponteau et al.
Counter et al. Proc. Natl. Acad. Sci. USA, vol. 91, pp. 2900-2904, Apr. 1, 1994.

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