Rapid and sensitive detection of antibiotic-resistant mycobacter

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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435 29, 435 32, C12Q 168

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active

057703736

ABSTRACT:
The invention relates to methods and oligonucleotide probe compositions useful for determining antibiotic resistance in Mycobacteria. Included are methods for freeing intact precursor ribosomal RNA from mycobacterial cells and for assaying the levels of pre-rRNA in the cells. Also claimed are methods useful in discovering new anti-mycobacterial therapeutic agents.

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