Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1994-05-05
1998-06-23
Sidberry, Hazel F.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 4241851, 424831, 530350, 530412, 530807, A61K 39102, A61K 3900, C07K 136, C07K 14285
Patent
active
057702136
ABSTRACT:
The present invention relates to P5 outer membrane protein of the non-typable Haemophilus influenzae bacterial strain and antibodies directed to P5 protein. The invention also relates to a method of isolating P5 protein and a vaccine composition for use in the treatment of non-typable Haemophilus influenzae infection.
REFERENCES:
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Munson et al, Infection & Immunity 61:4017-4020, 1993 Sep.
Hughes et al, ABSTRACTS of the 92nd General Meeting of the American Society for Microbiology, p. 106 Abst D-63.
Munson et al, Infection & Immunity 49:544-549, 1985.
Green et al. Infection & Immunity 61:1950-1957, 1993.
Houghten et al, VACCINES 86 New Approaches to Immunization, pp. 21-25, 1986.
Purification and Partial Characterization of Outer Membrane Proteins P5 and P6 from Haemophilus Influenzae Type b, American Society for Microbiology, R. Munson, Jr. and D. Granoff, May 1985.
Spinola, S. M., et al., The Major Outer Membrane Protein of Haemophilus ducreyi Is a Member of the OmpA Family of Proteins, Infection and Immunity, Apr. 1993, pp. 1346-1351.
Faden, H., et al., Otitis Media in Children. I. The Systemic Immune Response to Nontypable Haemophilus influenzae, 1989, The Journal of Infectious Diseases, vol. 160, No. 6, pp. 999-1004.
Loeb et al. Infection & Immunity 55:2612-2618, 1987.
L. van Alphen et al., Infection & Immunity, 56, 1800-1806 (1988).
T. Sirakova et al., Infection and Immunity, 62, 2002-2020 (1994).
American Cyanamid Company
Gordon Alan M.
Sidberry Hazel F.
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