Surgery – Truss – Pad
Patent
1982-09-30
1984-05-29
McCamish, Marion
Surgery
Truss
Pad
604 6, 128 1R, A61K 3100, A61M 514
Patent
active
044508417
ABSTRACT:
A novel acute care cerebral support system and method for treating severly ischemic brains is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the ventriculo-subarachnoid spaces. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability to the nutrient emulsion. The disclosed system and method have been shown to effectively exchange oxygen, carbon dioxide, glucose, and other metabolites in severely stroked brains. Significant restoration of oxidative metabolism and electrographic activity result from the disclosed treatment. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
REFERENCES:
patent: 3482575 (1969-12-01), Claff et al.
patent: 3516410 (1970-06-01), Hakim
patent: 3583387 (1971-06-01), Garner
patent: 3626950 (1971-12-01), Schulte
patent: 3669094 (1972-06-01), Heyer
patent: 3669116 (1972-06-01), Heyer
patent: 3690323 (1972-09-01), Wortman et al.
patent: 3753865 (1973-08-01), Belzer
patent: 3823091 (1974-07-01), Samejima
patent: 3894541 (1975-07-01), El-Shafei
patent: 3941119 (1976-03-01), Corrales
patent: 3946731 (1976-03-01), Lichtenstein
patent: 3989843 (1976-11-01), Chabert et al.
patent: 4110474 (1978-08-01), Lagow et al.
patent: 4148314 (1979-04-01), Yin
patent: 4163734 (1979-04-01), Sorensen et al.
patent: 4173224 (1979-11-01), Marx et al.
patent: 4173654 (1979-11-01), Scherer
Rodnight, R, Biochemistry Journal, vol. 57, p. 661.
Clark et al., Science, vol. 152, pp. 1755-1756 (1966).
Gollon, F. et al., Alabama Journal of Medical Science, vol. 4, p. 336 (1967).
Gollon, F. et al., The Physiologist, vol. 9, p. 191 (1966).
Sloviter, H. A. et al., Nature (London), vol. 216, p. 458 (1967).
Geyer, R. P. Federation Proceedings, vol. 29, No. 5, Sep.-Oct., 1970.
Geyer, R. P., Med u Ernohn, vol. 11, p. 256 (1970).
Krone, W. et al., Biochemika et Biophysica Acta, vol. 372, pp. 55-71 (1974).
Rosenblum, W. I., "Fluorocarbon Emulsions and Cerebral Microcirculation," Federation Proceedings, vol. 34, No. 6, p. 1493 (May, 1975).
Kontos, H. A. et al., "Role of Tissue Hypoxemia in Local Regulation of Cerebral Microcirculation," American Journal of Physiology, vol. 363, pp. 582-591 (1978).
Hare et al., "Rapid and Sensitive Ion-Exchange Fluorometric Measurement of G-Aminobutyric Acid in Physiological Fluids", Anal. Biochem., vol. 101, pp. 349-355 (1980).
Navari et al., Res. Exp. Med., vol. 170, pp. 169-180 (1977).
Clark et al., Fed. Proc., vol. 34, pp. 1468-1477 (1979).
Osterholm, J. L., Pathophysiology of Spinal Cord Injury, C. C. Thomas, Springfield, Ill., (1978).
Pappenheimer, J. R. et al., "Perfusion of the Cerebral Ventricular System in Unanestized Goats," Am. J. Physiol., vol. 203, No. 5, pp. 763-774 (1962).
Sklar, Frederick H. et al., "Recirculatory Spinal Subarachnoid Perfusions in Dogs: A Method for Determining CSF Dynamics Under Non-Steady State Conditions," Neurosurgery, vol. 1, No. 1, pp. 48-56 (1977).
Sloviter, Henry A. et al., "Erythrocyte Substitute for Perfusion of Brain," Nature, vol. 216, pp. 458-460 (Nov. 4, 1967).
Hansebout, Robert R. et al., "Oxygenated Fluorocarbon Perfusion as Treatment of Acute Spinal Cord Compression Injury in Dogs," J. Neurosurg., vol. 55, pp. 725-732 (1981).
Seigel et al., Basic Neurochemistry, 2d Little Brown Boston (1978), p. 297.
Astrup, et al., "The Increase in Extravellular Potassium Concentration in the Ischemic Brain in Relation to the Preischemic Functional Activity and Cerebral Metabolic Rate," Brain Research, 199:161-174 (1980).
Ames, et al., "Cerebral Ischemia: II. The No-Reflow Phenomenon," Am. J. Pathol., vol. 52, No. 2, pp. 437-448 (1968).
Berkenbosch et al., "Influence of the CSF Bicarbonate Concentration on the Ventilatory Response to CO.sub.2 in Relation to the Location of the Central Chemoreceptors," Respiration Physiology, 35:215-236 (1978).
Britton et al., "Effect of Cerebral Extracellular Fluid Acidity on Total and Regional Cerebral Blood Flow," Journal of Applied Phys., vol. 47, pp. 818-826, Oct.-Dec. (1979).
Brown et al., Fluorocarbon Sonicated as a Substitute for Erythrocytes in Rat Liver Perfusion", Surgery, vol. 71, No. 3, pp. 388-394 (Mar. 1972).
Callaghan, et al., "CSF Perfusion to Treat Intraventricular Penicillin Toxicity", Arch. Neurol., vol. 38, pp. 390-391 (1981).
Carey, et al., "The Effect of Severe Hypoglycemia Upon Cerebrospinal Fluid Formation, Ventricular Iodide Clearance, and Brain Electrolytes in Rabbits", J. Neurosurg., vol. 54, pp. 370-379 (1981).
Chiang, et al., "Cerebral Ischemia: Vascular Changes", American Journal of Pathology, vol. 52, pp. 455-476, (1968).
Clark et al., "Can Fluorocarbon Emulsions be Used as Artificial Blood?" Triangle, vol. 11, No. 4, pp. 115-122 (1972).
Curtis, C. "Blood and Money", Forbes, pp. 100-102 (Nov. 9, 1981).
Dirks, et al., "Fluorocarbon Perfusion Medium Applied to the Isolated Rat Brain", Journal of Pharmacological Methods, 4:95-108 (1980).
Fischer et al., "Reassessment of Cerebral Capillary Changes in Acute Global Ischemia and Their Relationship to the `No-Reflow Phenomenon`", Stroke, vol. 8, pp. 36-39 (1977).
Fischer, E. "Impaired Perfusion Following Cerebrovascular Stasis," Arch. Neurol., vol. 29, pp. 361-366 (Dec. 1973).
Fritschka, et al., "Total and Regional Cerebral Blood Flow During Perfusion from the Lateral Ventricle to the Cisterna Magna in Conscious Dog: Effect of Hemorrhagic Hypotension and Retransfusion on Cerebral Blood Flow," Circulatory Shock, 7:333-342 (1980).
Hossmann, et al., "Cation Activities in Reversible Ischemia of the Cat Brain", Stroke, vol. 8, pp. 77-81 (1977).
Fritschka, et al., "Increased Free Fatty Acid Turnover in CSF During Hypotension in Dogs", American J. Physiology, vol. 236, pp. H802-H807, (1979).
Grote, J., "Cerebral Oxygen Supply in Brain Edema and During Ventriculo-Cisternal Perfusion", Adv. in Exp. Med. Biol, vol. 75, pp. 313-324 (1975).
Geyer, et al., "9 Survival of Rats Totally Perfused with a Fluorocarbon-Detergent Preparation", Organ Perfusion and Preservation, pp. 85-96 (1968).
Heisey, et al., "Bulk Flow and Diffusion in the Cerebrospinal Fluid System of the Goat", American J. of Physic., vol. 203, pp. 775-781 (1962).
Glogar et al., "Fluorocarbons Reduce Myocardial Ischemic Damage After Coronary Occlusion", Science, vol. 211, pp. 1439-1441 (Mar. 1981).
Hossmann et al., "Reversibility of Ischemic Brain Damage", Arch. Neurol., vol. 29, pp. 375-384 (Dec. 1973).
Gould et al., "How Good are Fluorocarbon Emulsions as O.sub.2 Carriers?" Departments of Surgery, Michael Reese Hospital et al., pp. 1-3.
Hossmann et al., "Resuscitation in the Monkey Brain After 1 H Complete Ischemia", 1. Physiological and Morphological Observations, Brain Research, 81:59-74 (1974).
Javid, et al., "Hypothermic Ventricular Perfusion-Evaluation of Use in Cerebrovascular Occlusion", New York State Journal of Medicine, pp. 248-251 (Jan. 15, 1967).
Kleihues, et al., "Purine Nucletide Metabolism in the Cat Brain After One Hour of Complete Ischemia", Journal of Neurochemistry, vol. 23, pp. 417-425 (1974).
Min-Chu Liew et al., "A Technique for Perfusing the Cerebrospinal Fluid Spaces of the Cat from Lateral Ventricle via the Cisterna Magna to the Cortical Subarachnoid Space", J. Physiol., pp. 20P-21P (Dec. 1977).
Martins, et al., "Sources of Error in Measuring Cerebrospinal Fluid Formation by Ventriculocisternal Perfusion", Journal of Neurosurgery and Psychiatry, vol. 40, pp. 645-650 (1977).
Mizoi, et al., "Experimental Study of New Cerebral Protective Substances-Functional Recovery of Severe, Incomplete Ischaemic Brain Lesions Pretreated with Mannitol and Fluorocarbon Emulsion, Acta Neurochirurgica 56, pp. 157-166 (1981).
Peerless, et al., "Protective Effect of Fluosol-DA in Acute Cerebral Ischemia", Stroke vol. 12, No. 5, pp. 558-563 (1981).
R
McCamish Marion
Swisher Nancy A. B.
Thomas Jefferson University
LandOfFree
Stroke treatment utilizing extravascular circulation of oxygenat does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Stroke treatment utilizing extravascular circulation of oxygenat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Stroke treatment utilizing extravascular circulation of oxygenat will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1392317