Pyridine-substituted benzyl alcohols as leukotriene antagonists

Details Pyridine-substituted benzyl alcohols as leukotriene antagonists Pyridine-substituted benzyl alcohols as leukotriene antagonists

1992-04-13

1996-04-09

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142315, 5142335, 5142352, 5142358, 5142368, 5142372, 514255, 514277, 514316, 514318, 514332, 514335, 514341, 514342, 514343, 514351, 544114, 544124, 544125, 544128, 544129, 544133, 544134, 544137, 544141, 544146, 544148, 544149, 544152, 544158, 544162, 544163, 544170, 544171, 544172, 544174, 544175, 544358, 544359, 544363, 544366, 544369, 544372, 544379, 544399, 544400, 546153, 546159, 546162, 546168, 546174, 546175, 546187, 546194, 546208, 546209, 546210, 546214, 546229, 546230, 546232, 546233, 546234, 54

Patent

active

055062270

ABSTRACT:
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

REFERENCES:
patent: 4760068 (1988-07-01), Terao et al.
patent: 5004743 (1991-04-01), Young et al.
Chemical Abstract, vol. 117 No. 131085p, 1992, Belley et al, "Preparation of Saturated Hydroxyalkylquinolines Acids as Leukotiene Antagonists.".

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