PGI.sub.2 Salts

Details PGI.sub.2 Salts PGI.sub.2 Salts

1977-07-28

1985-02-12

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548252, 549415, 514935, C07D307935

Patent

active

044992939

ABSTRACT:
Prostaglandin (PG.sub.1) derivatives having a 5,6-didehydro feature, for example an enol ether of the formula ##STR1## said derivatives having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.

REFERENCES:
Gryglewski et al., Nature, vol. 273, Jun. 1978, pp. 765-767.
Moncada et al., I, Nature, vol. 273, Jun. 1978, pp. 767-768.
Moncada et al., II, Prostacyclin, edited by J. R. Vane and S. Bergstrom, Raven Press, New York, (1979), pp. 5-16.
Johnson et al., Prostaglandins 12(6), 1976, 915-928.
Pace-Asciak et al., Biochem. 10(20), 1971, 3657-3664.
Nicolaou et al., J.C.S. Chem. Comm., 1977, pp. 331-332.
Corey et al., J.A.C.S. 99(6), Mar. 16, 1977, pp. 2006-2008.
Fried et al., Proc. Natl. Acad. Sci., U.S.A., vol. 74, No. 6, Jun. 1977, pp. 2199-2203.

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