Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...
Patent
1994-11-10
1996-04-09
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Phosphorus containing other than solely as part of an...
558169, A61K 31685
Patent
active
055062172
ABSTRACT:
This invention pertains to the synthesis and usc as anti-cancer therapeutic agents of a group of substances with a glycerol backbone linked to phosphonocholinc, or other phosphorus-containing head groups, of the following formula: ##STR1## wherein n is 0 to 14 and R.sub.1 is an alkyl group containing 12 to 20 carbon atoms, R.sub.2 is a methyl group, n=0 to 14 and m=2 to 10, or enantiomer thereof, or mixture of stereoisomers. This invention also pertains to the following formula: ##STR2## wherein n is 15 to 17; R1 is an alkyl group: m is 0 to 2; T is an oxygen atom or a methylene; and R.sub.2 is a choline group and therapeutically effective pharmaceutically acceptable salts thereof. These thiophosphonolipids are useful for treating cancer in a mammal in need of cancer treatment.
REFERENCES:
patent: 4408052 (1983-10-01), Hozumi et al.
patent: 4515722 (1985-05-01), Yang et al.
patent: 5219845 (1993-06-01), Salari et al.
patent: 5369097 (1994-11-01), Salari et al.
Chemical Abstracts, vol. 114, 1991, p. 767, Abstract No. 82129h; German Democratic Rep. 278,800.
Yuan, W. et al., "Phosphate-Containing Phospholipid Analogues as Tight-Binding Inhibitors of Phosphollipase-A.sub.2,"J. Am. Chem. Soc., vol. 110 (1988), pp. 2665-2666.
Carter, S. K. et al., "Chemotherapy of Cancer," Second Edition; John Wiley and Sons; New York, 1981; Appendix C.
Chemical Abstracts, vol. 117 (1992), p. 794, Abstract No. 90393s; Ries, U. J. et al., "Synthesis of Alkylphosphonates, a New Class of Antineoplastic Agents,"Chem. Phys. Lipids, vol. 61, No. 3 (1992), pp. 225-234.
Chemical Abstracts, vol. 103, No. 21 (1985), p. 701, Abstract No. 178451f; Japan Kokai Tokyo Koho 60-069088.
Bittman Robert
Salari Hassan
Ambrose Michael G.
Richter Johann
The University of British Columbia
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