Reduction of trichloromethylpyridines to dichloromethylpyridines

Details Reduction of trichloromethylpyridines to dichloromethylpyridines Reduction of trichloromethylpyridines to dichloromethylpyridines

1983-03-14

1985-02-12

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546345, C07D21326

Patent

active

044992769

ABSTRACT:
2(6)-(Trichloromethyl)pyridines are reduced to the corresponding 2(6)-(dichloromethyl)pyridines by treatment with a strong base and an anionic reductant derived from a reductant source material selected from the group consisting of chloroform, dimethylsulfoxide, dimethylsulfone, and a ketone having a base-abstractable hydrogen, said treatment taking place in the presence of a polar, non-hydroxylic solvent and/or a phase transfer catalyst.

REFERENCES:
patent: 3420833 (1969-01-01), Taplin
patent: 3591596 (1971-07-01), Wang et al.
patent: 4062962 (1977-12-01), Noveroske
patent: 4143144 (1979-03-01), Tobol et al.
patent: 4260766 (1981-04-01), Morris

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