Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-08-02
1997-01-14
Fleisher, Mindy
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435 681, 514 12, 514834, 530381, 530382, 530829, 530830, A61K 3836, A61K 3516, C07K 14745, C07K 116
Patent
active
055939686
ABSTRACT:
A virus-inactivated Factor-Xa preparation with at least 100 units coagulation factor activity per mg protein is described, wherein this preparation is produced by activation of a corresponding starting material and subsequent treatment for the inactivation of infectious agents, particularly viruses. By incubation, the preparation obtained in this manner is transformed into a stable beta-Factor Xa preparation. In addition, the use of the present preparation for the treatment of hemophilia A inhibitor patients is disclosed.
REFERENCES:
patent: 4297344 (1981-10-01), Schwinn et al.
patent: 4495278 (1985-01-01), Thomas
patent: 4501731 (1985-02-01), Tishkoff et al.
patent: 4640834 (1987-02-01), Eibl et al.
patent: 4687664 (1987-08-01), Philapitsch et al.
patent: 5410022 (1995-04-01), Eibl et al.
Radcliffe et al., "Comparisions of the Molecular Forms of Activated Bovine Factor X", J. Bio. Chem., 248(19):6788-6795 (1973).
Radcliffe et al., "The Purification and Properties of Activated Factor X", J. Bio. Chem., 247(23):7735-7742 (1972).
Yue et al., "Isolation of the High Molecular Form of Bovine Factor X and Some of its Physical Properties", Biochimica et Biophysica Acta 490:350-362 (1977).
Novoa et al., "Improved Procedures for the Purification of Selected Vitamin K-Dependent Proteins", Preparative Biology, 6(5):307-338 (1976).
J. C. Giddings, "Molecular Genetics and Immunoanalysis in Blood Coagulation", 1988, pp. 46-52.
Jesty et al., "The Activation of Cleavage Sites in the Alternative Pathays and Characterization of the Cooh-Terminal Peptide*", The Journal of Biological Chemistry, vol. 250, No. 12, Jun. 1975, pp. 4497-4504.
Jesty et al., "The Mechanism of Activation of Factor X", The Journal of Biological Chemistry, vol. 249, No. 17, Sep. 1974, pp. 5614-5622.
Fujikawa et al., "Activation of Bovine Factor X (Stuart Factor): Conversion of Factor X.sub.a.alpha. to Factor X.sub.a.beta. ", Proc. Nat. Acad. Sci., vol. 72, No. 9, Sep. 1975, pp. 3359-3363.
Teng et al., "Production of Factor X and Factor Xa Variants with Thrombin, Acutin and by Autolysis", Thrombosis Research, vol. 22, No. 1/2, 1981, pp. 213-220.
Bajaj et al., "Simultaneous Purification of Bovine Prothrombin and Factor", The Journal of Biological Chem., vol. 248, No. 22, Apr. 1973, pp. 7729-7741.
Mertens et al., "Pathways in the Activation of Human Coagulation Factor X", J. Biochem. vol. 185, 1980, pp. 647-658.
Wolf et al., "Design of Constructs for the Expression of Biologically Recombinant Human Factors X and Xa", J. Bio. Chem., vol. 266, No. 21, Jul. 1991, pp. 13726-13730.
H. G. J. Brummelhuis, "Preparation of the Prothrombin Complex", Acad. Pres, 1980, pp. 117-128.
Miletich et al., "The Synthesis of Sulfated Dextran Beads for Isolation of Human Plasma Coagulation Factors II, IX, and X.sup.1 ", Analytical Biochem., 105, 1980, pp. 304-310.
Kisiel et al. "Factor X Activating Enzyme from Russell's Viper Venom: Isolation & Characterization" Biochemistry 15(22) 4901-4906 1976.
Johann Eibl
Schwarz Hans-Peter
Turecek Peter
Degen Nancy J.
Fleisher Mindy
Immuno Aktiengesellschaft
LandOfFree
Virus-inactivated factor Xa preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Virus-inactivated factor Xa preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Virus-inactivated factor Xa preparation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1388201