Diagnostic method for the immunological determination of NCAM

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

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435 792, 435 793, 435 794, 435962, G01N 3353

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active

055938981

ABSTRACT:
The invention relates to an improved diagnostic method for the immunological determination of NCAM by means of specific binding partners, the one specific binding partner being immobilized on a carrier and the extent of the binding of the analyte to the first specific binding partner being determined by means of a second binding partner which is specific for the analyte and which is labeled either directly or via further binding partners.

REFERENCES:
patent: 5376557 (1994-12-01), Schmitt
"NCAM Biosynthesis In Brain", Nybroe et. al., Neurochem. Int., 12(3):251-262 (1988).
"Expression Of The Embryonal Neural Cell Adhesion Molecule N-Cam In Lung Carcinoma. Diagnostic Usefulness Of Monoclonal Antibody 735 For The Distinction Between Small Cell Lung Cancer And Non-Small Cell Lung Cancer", R. E. Kibbelaar et. al., Journal of Pathology, 159:23-28 (1989).
"NZB Mouse System For Production Of Monoclonal Antibodies To Weak Bacterial Antigens: Isolation Of An IgG Antibody To The Polysaccharide Capsules Of Escherichia coli K1 And Group B Meningococci", Frosch et. al., Proc. Natl., Acad., Sci. USA, 82:1194-1198 (1985).
"Quantification Of The D2-Glycoprotein In Amniotic Fluid And Serum From Pregnancies With Fetal Neural Tube Defects", Ibsen et. al., Journal of Neurochemistry, 41:2 pp. 363-366, (1983).
"An IgG Monoclonal Antibody To Group B Meningococci Cross-Reacts With Developmentally Regulated Polysialic Acid Units Of Glycoproteins In Neural And Extraneural Tissues", Finne et. al., Journal Of Immunology, 138(12):4402-4407 (1987).
"Structure And Biosynthesis Of Surface Polymers Containing Polysialic Acid In Escherichia coli", Rohr et. al., The Journal Of Biological Chemistry, 255(6):2332-2342 (1980).
"Biosynthesis of the Polysialic Acid Capsule In Escherichia coli K1", Weisgerber et. al., The Journal Of Biological Chemistry, 265(3):1578-1587 (1990).

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