Nucleic acids encoding drosophila tipE cation channel proteins a

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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536 235, 4353201, 4352402, 4352523, 43525411, C12N 1512, C12N 510, C12N 121

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055938620

ABSTRACT:
The present invention provides for the isolation of genomic fragments from Drosophila melanogaster encoding tipE protein, which protein is required for expression of functional voltage dependent cation channels. A positional cloning coupled with transformation strategy was used to identify and isolate the tipE gene. A cDNA corresponding to the gene encoding tipE is also provided and characterized. In another aspect of the present invention, there is provided a functional voltage dependent cation channel. Methods for making and using the cation channel are also provided.

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