Method for prevention of graft versus host disease

Details Method for prevention of graft versus host disease Method for prevention of graft versus host disease

1994-05-26

1997-01-14

Budens, Robert D.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

4241731, 43524027, 514 11, 53038875, A61K 39395, A61K 3813, C07K 1638

Patent

active

055936776

ABSTRACT:
A method is disclosed for the treatment and prevention of graft versus host disease in man through the combined use of anti-CD8 monoclonal antibodies and a CD4.sup.+ cell inactivator.

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Korngold & Sprent, Transplantation, 44:335 (1987).
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Pals et al., J. Immuno., 132:1669 (1984).
Ferrara et al., J. Immunol. 137:1874 (1986).
R. Parkman, J. Immunol., 136:3543 (1986).
Daley et al., Blood, 70:960 (1987).
Apperley et al., Brit. J. Hematol., 69:239 (1988).
Martin et al., Blood 66:664 (1985).

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