Method of making a porous matrix particle

Details Method of making a porous matrix particle Method of making a porous matrix particle

1993-06-10

1997-05-13

Wax, Robert A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Solid support and method of culturing cells on said solid...

435 703, 435174, 424488, 424484, C12N 506, C12P 2102

Patent

active

056291914

ABSTRACT:
A porous particle having a generally isopycnic density with liquid growth medium, a sponge-like character and a diameter of less than 2 mm which is formed from a homogenous biologically compatible matrix is described. This particle is useful in various systems for culturing anchorage-dependent and -independent cells, and is adaptable to large scale tissue culture which permits harvesting of cell products. The method of making such a particle includes preparing a solution containing a biologically compatible material, forming droplets from the solution, freezing the droplets, drying the droplets by sublimation to form a particle, and crosslinking the biologically compatible material in the particle.

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