Chemistry: analytical and immunological testing – Immunochemical pregnancy determination
Patent
1992-07-07
1996-04-09
Parr, Masrgaret
Chemistry: analytical and immunological testing
Immunochemical pregnancy determination
436501, 436 65, 436814, 436817, 435 71, 435 793, G01N 3353, G01N 3374, G01N 3376
Patent
active
055061508
ABSTRACT:
A prenatal screening test for risk of Down's Syndrome in a foetus, which is carried out on a maternal blood sample before the beginning of the third trimester of pregnancy, by assaying the sample for a metabolite of feto-placental activity which is affected by the presence of Down's Syndrome, selected from unconjugated oestriol; progesterone; 16-alpha-hydroxy-dehydroepiandrosterone sulphate (16-alpha-hydroxy-DHEAS); and dehydroepiandrosterone sulphate (DHEAS). An additional assay for alpha-fetroprotein and/or human chorionic gonadotrophin may be included.
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Canick Jacob A.
Cuckle Howard S.
Haddow James E.
Wald Nicholas J.
3i Research Exploitation Limited
Grun James L.
Parr Masrgaret
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