Method for galenically preparing a therapeutic composition based

Details Method for galenically preparing a therapeutic composition based Method for galenically preparing a therapeutic composition based

1995-06-05

1997-05-13

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424439, 424458, A61K 914

Patent

active

056290225

ABSTRACT:
Preparation method for preparing a therapeutical composition for internal use, particularly to be administered by mouth, in galenical presentation, and containing at least one active principle in solid form adsorbed on a substrate, the active product being distributed therein as finely dispersed microparticles. The method includes dissolving the starting active principle in an appropriate solvent, impregnating the solution thus formed on a food support having an appropriate structure and pharmaceutically compatible with the active principle, and evaporating the solvent from the solution adsorbed in the support by causing the reconstitution of the active principle by formation of microcrystals adsorbed on the walls of the substrate and within the substrate. The solvent is comprised of a binary system including a main solvent of organic nature and an adjuvent of the solid type at room temperature and soluble in the main solvent. The adjuvent additionally has lubricating properties.

REFERENCES:
patent: 4206209 (1980-06-01), Kracauer
patent: 4985252 (1991-01-01), Jung et al.
patent: 5043167 (1991-08-01), Rotini et al.
patent: 5139774 (1992-08-01), Meinard et al.

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