Process and apparatus for fragmenting biomaterials

Details Process and apparatus for fragmenting biomaterials Process and apparatus for fragmenting biomaterials

1993-06-01

1996-04-09

Wityshyn, Michael G.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352831, 4352851, 422 99, 422243, 935 19, 239338, C12Q 168, C12M 100, C12N 1510

Patent

active

055061001

ABSTRACT:
Described is an improved process for fragmenting a biomaterial and isolating and recovering a component thereof. The preferred improved process includes the step of performing the fragmentation by nebulizing a liquid medium containing the biomaterial. A preferred process for fragmenting isolated DNA includes the step of nebulizing a fluid containing the DNA. This preferred process provides randomness superior to prior known DNA fragmentation methods, as well as other important advantages. Improved nebulization devices are also described.

REFERENCES:
patent: Re33642 (1991-07-01), Lester
patent: 4161282 (1979-07-01), Erb
patent: 4560519 (1985-12-01), Cerny
patent: 4612926 (1986-09-01), Boiarski
patent: 4805609 (1989-02-01), Robeas et al.
Young, et al. "Continuous Aerosol Therapy System Using A Modified Collision Nebulizer" J. Clin. Microbiol. 5(2) 131-136 1977.

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