Human phosphoprotein

Details Human phosphoprotein Human phosphoprotein

1996-10-29

1999-06-29

Grimes, Eric

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 2431, C12N 1511, C12N 1512

Patent

active

059170280

ABSTRACT:
The present invention provides a novel human phosphoprotein (hPSHP) and polynucleotides which identify and encode hPSHP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding hPSHP. The invention also provides pharmaceutical compositions containing hPSHP or agonists and antagonists to hPSHP, and in the use of these compositions for the treatment of diseases associated with hPSHP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding hPSHP for the treatment of diseases associated with the expression of hPSHP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, to hybridize to the genomic sequence or transcripts of polynucleotides encoding hPSHP or anti hPSHP antibodies which specifically bind to hPSHP.

REFERENCES:
patent: 5656654 (1997-08-01), Buzzetti et al.
Peyrollier, K., et al., ".alpha. Endosulfine is a novel molecule, structually related to a family of phosphoproteins," Biochemical and Biophysical Research Communications, 223:583-586 (1996).
EMEST Database entry Hsaa26133, Accession No. AA126133; Nov. 30, 1996, Hillier, L., et al., "Homo sapiens cDNA clone 511419 5 similar to TR:G162688 G1626588 cAMP-regulated phosphoprotein," XP002054125.
EMEST Database entry Hs56456, Accession No. T78564; Apr. 8, 1995, Hillier, L., et al., "Homo sapiens cDNA clone 72348 5' similar to SP:A35308, A35308 cAMP-regulated phosphoprotein, 16K," XP002054126.
Walaas, SI et al., "A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions" Nature 301:69-71 (1983).
Hemmings, HC et al., "DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1" Nature 310:503-505 (1984).
Halpain, S et al., "Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices" Nature 343:369-372 (1990).
Horiuchi, A et al., "Purification and cDNA Cloning of ARPP-16, a cAMP-regulated Phosphoprotein Enriched in Basal Ganglia, and of a Related Phosphoprotein, ARPP-19" J Biol Chem 265(16) 9476-9484 (1990) (Accession GI 162690).
Girault, JA et al., "Differential Expression of ARPP-16 and ARPP-19, Two Highly Related cAMP-Regulated Phosphoproteins, One of Which Is Specifically Associated with Dopamine-Innervated Brain Regions" J Neurosci 10(4):1124-1133 (1990).
Brene, S et al., "Expression of mRNAs Encoding ARPP-16/19, ARPP-21, and DARPP-32 in Human Brain Tissue" J Neurosci 14(3):985-998 (1994) (Accession GI 741603).
Pincus, DW et al., "Vasoactive intestinal peptide regulation of neuroblast mitosis and survival: role of cAMP" Brain Res 514:355-357 (1990).
Girault, JA et al., "Regulation by cAMP and vasoactive intestinal peptide of phosphorylation of specific proteins in striatal cells in culture" Proc. Natl. Acad. Sci. 85:7790-7794 (1988).

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