Tricyclic Benzazepine vasopressin antagonists

Details Tricyclic Benzazepine vasopressin antagonists Tricyclic Benzazepine vasopressin antagonists

1996-04-25

1998-04-07

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540542, 540576, 540586, A61K 3155, C07D22300, C07D22314

Patent

active

057365385

ABSTRACT:
Tricyclic compounds of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and processes for preparing such compounds.

REFERENCES:
patent: 5512563 (1996-04-01), Albright
Albright, Chemical Abstract 123:313792 for Canadian Patent 2,128,955 Jan. 30,1995.
International Union of Pure and Applied Chemistry (IUPAC), vol. 82, 1960, p. 5566.
Drug Evaluations, 6th Ed., 1986, Amer. Medical Assn., pp. 160-162.
Cecil Textbook of Medicine, 19th Ed., 1992, Wynoaarden, M.D., Editor pp. 2075-2079.
Yamamura, et al., Science, 252 pp. 572-574, 1991.
Yamamura, et al., Br. J. Pharmacol., 105 pp. 787-791 1992).

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