Encapsulation compositions, and methods

Details Encapsulation compositions, and methods Encapsulation compositions, and methods

1995-03-03

1999-06-29

Lovering, Richard D.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

264 43, 264 432, 424425, 424484, 424491, 435177, 514866, 514965, C12N 1102, C12N 1110, A61K 950

Patent

active

059167904

ABSTRACT:
The present invention generally relates to novel encapsulation compositions and methods. In particular, the invention relates to stabilized microcapsule compositions which comprise a layer of a crosslinked, mixed functionality, polymer matrix, and methods for their preparation. The encapsulated compositions may comprise the crosslinked polymer matrix layer as an inner layer, an outer layer, or an intermediate layer of an overall encapsulated composition. The compositions will generally also comprise a biological material, e.g., cells, proteins, and the like, encapsulated within the composition. The compositions and methods of the invention are useful in a variety of applications, including cell culturing and transplant therapy.

REFERENCES:
patent: 4164559 (1979-08-01), Miyata et al.
patent: 4177038 (1979-12-01), Biebricher et al.
patent: 4352883 (1982-10-01), Lim
patent: 4391909 (1983-07-01), Lim
patent: 4407957 (1983-10-01), Lim
patent: 4409331 (1983-10-01), Lim
patent: 4543332 (1985-09-01), Jao et al.
patent: 4592098 (1986-06-01), Magnes
patent: 4663286 (1987-05-01), Tsang et al.
patent: 4671954 (1987-06-01), Goldberg et al.
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4689293 (1987-08-01), Goosen et al.
patent: 4696286 (1987-09-01), Cochrum
patent: 4744933 (1988-05-01), Rha et al.
patent: 4749620 (1988-06-01), Rha et al.
patent: 4789550 (1988-12-01), Hommel et al.
patent: 4791061 (1988-12-01), Sumino et al.
patent: 4798786 (1989-01-01), Tice et al.
patent: 4803168 (1989-02-01), Jarvis
patent: 4806355 (1989-02-01), Goosen et al.
patent: 4824916 (1989-04-01), Kerschner et al.
patent: 4902295 (1990-02-01), Walthall et al.
patent: 4956128 (1990-09-01), Hommel et al.
patent: 5041292 (1991-08-01), Feijen
patent: 5059416 (1991-10-01), Cherukuri et al.
patent: 5084350 (1992-01-01), Chang et al.
patent: 5204108 (1993-04-01), Ilium
patent: 5227298 (1993-07-01), Weber et al.
patent: 5264359 (1993-11-01), Enami et al.
patent: 5286495 (1994-02-01), Batich et al.
patent: 5306500 (1994-04-01), Rhee et al.
patent: 5334640 (1994-08-01), Desai et al.
patent: 5362478 (1994-11-01), Desai et al.
patent: 5487895 (1996-01-01), Dapper et al.
U.S. application No. 08/186,327, filed Jan. 24, 1994.
Abuchowski et al., "Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol," J. Biol. Chem. 252:3578-3581 (1977).
Brendel et al., "Improved functional survival of human islets of langerhans in three-dimensional matrix culture," Cell Trans. 3:427-435 (1994).
Chao et al., "Entrapment of cultured pancreas islets in three-dimensional collagen matrices," Cell Transplantation 1:51-60 (1992).
Chiang et al., "Synthesis of ionic conducting interpenetrating polymer networks," Polymer Communications pp. 34-35 (Butterworth & Co.) 1987.
Chaikof et al., "Surface topography of crosslinked poly(ethylene oxide)/polysiloxane networks in the dry and hydrated states," Polymer Communications 31:182-185 (1990).
Sun and O'Shea, "Microencapsulation of Living Cells--A Long-Term Delivery System," Journal of Controlled Release, 2:137-141 (1985).
Corkhill et al., "Synthetic hydrogels: 7. High EWC semi-interpenetrating polymer networks based on cellulose esters and N-containing hydrophilic monomers," Polymer 31:1526-1537 (1990).
Goosen et al., Fundamentals of Animal Cell Encapsulation and Immobilization, Ch. 6, pp. 114-142 (CRC Press (1993)).
Lim et al., "Microencapsulation of living cells and tissues," J. Pharm. Sci. 70:351-354 (1981).
Lim et al., "Microencapsulated islets as bioartificial endocrine pancreas," Science 210:908-910 (1981).
Lum et al., "Prolonged reversal of diabetic state in NOD mice by xenografts of microencapsulated rat islets," Diabetes 40:1511-1516 (1993).
Ohgawara et al., "Maintenance of embedded pig pancreatic pseudo-islets in a collagen gel matrix: study of the effect of hydrocortisone, a collagenase inhibitor, and nicotinamide on collagenolysis and the morphogenesis of pancreatic islet-cells in collagen gel matrix," In Vitro Cell. Dev. Biol. 26:348-352 (1990).

Affiliated with

Also associated with

Rating

Encapsulation compositions, and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Encapsulation compositions, and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Encapsulation compositions, and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1375075