Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1997-02-04
1999-06-29
Ulm, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 71, 435 72, 4352523, 4353201, 536 235, C12N 1512
Patent
active
059167661
ABSTRACT:
Human Marco scavenger receptor polypeptides (HMarcoSR) and DNA (RNA) encoding such HMarcoSR and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such HMarcoSR for the treatment of various cardivascular disorders, gangrene, and loss of fuunction in the extremeties. Antagonists against such HMarcoSR and their use as a therapeutic to treat various cardivascular disorders, gangrene, and loss of fuunction in the extremeties are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the HMarcoSR and for detecting altered levels of the polypeptide in a host.
REFERENCES:
Elomaa, et al. Cell vol. 80: pp. 603-609, Feb. 24, 1995.
Accession No. R09347, 1995, Hillier et al., "The WasU-Merck Est Project".
Adamou John
Elshourbagy Nabil
Gross Mitchell
Lysko Paul
Hecht Elizabeth J.
King William T.
SmithKline Beecham Corporation
Ulm John
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