Human phosphatidylinositol synthase

Details Human phosphatidylinositol synthase Human phosphatidylinositol synthase

1996-12-10

1999-06-29

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 701, 435 711, 4353201, 435325, 4352523, 43525411, 536 231, 536 232, 536 243, C12N 1511, C12N 1563, C12N 120, C07N 2104

Patent

active

059167645

ABSTRACT:
The present invention provides a human phosphatidylinositol synthase (PISH) and polynucleotides which identify and encode PISH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PISH and a method for producing PISH. The invention also provides for agonists, antibodies, or antagonists specifically binding PISH, and their use, in the prevention and treatment of diseases associated with expression of PISH. The invention also provides for the use of PISH in screening for antiprotozoal and antifungal therapeutics. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding PISH for the treatment of diseases associated with the expression of PISH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding PISH.

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