SH3-containing proteins

Details SH3-containing proteins SH3-containing proteins

1997-11-13

1999-06-29

Lau, Kawai

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 691, 4352523, 43525411, 4353201, 514 44, 536 235, C12Q 168, C12P 2102, C12N 1563, C07H 2104

Patent

active

059167530

ABSTRACT:
The invention provides a human SH3-containing protein (HS3C) and polynucleotides which identify and encode HS3C. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of HS3C.

REFERENCES:
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Aspenstrom, P. "A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton." Current Biology (Jun. 1997), vol. 7, No. 7, pp. 479-487.
Musacchio, A., et al., "Structure and Function of the SH3 Domain," Prog. Biophys. Molec. Biol., 61:283-297 (1994).
Pawson, T. and Gish, G., "SH2 and SH3 Domains: From Structure to Function," Cell, 71:359-362 (1992).
Ridley, A. and Hall, A., "The Small GTP-Binding Protein rho Regulates the Assembly of Focal Adhesions and Actin Stress Fibers in Response to Growth Factors," Cell, 70:389-399 (1992).
Chan, D., et al., "Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains," The EMBO Journal, 15(5):1045-1054 (1996) (GI 1255032 and GI 1255033).
Feng, S., et al., "Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions," Science, 266:1241-1246 (1994).
Charbonneau, H., "1002 Protein PHosphatases" Annu. Rev. Cell Biol., 8:463-93 (1992).
McPhail, L.C., "SH3-dependent Assembly of the Phagocyte NADPH Oxidase," J. Exp. Med., 180(6):2011-2456 (1994).
Chan, D., et al., (GI 1255032 and GI1255033), GenBank Sequence Database (Accession U40751) National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20894 (1996).
Fujiwara, T. et al. Submission to GenBank database, accession No. D58431, available at least as of May 21, 1996.

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