Human phosphatase inhibitor protein

Details Human phosphatase inhibitor protein Human phosphatase inhibitor protein

1996-12-13

1999-06-29

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 235, 536 231, 435 692, 4352523, 4353201, 435325, C12N 1512, C12N 1563, C12N 121, C07K 1447

Patent

active

059167491

ABSTRACT:
The present invention provides a novel human phosphatase inhibitor protein (HPIP) and polynucleotides which identify and encode HPIP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPIP and a method for producing HPIP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPIP, and their use, in the prevention and treatment of diseases associated with expression of HPIP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPIP for the treatment of diseases associated with the expression of HPIP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPIP.

REFERENCES:
Kaufman, JF et al., "The class II molecules of the human and murine major histocompatibility complex" Cell 36(1):1-13 (1984).
Lanzavecchia, A., "Antigen-specific interaction between T and B cells"Nature 314(6011):537-539 (1985).
Peters, PJ et al., "Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments" Nature 349(6311):669-676 (1991).
Cambier, JC et al., "Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes" Nature 327(6123):629-632 (1987).
Mooney, NA et al., "Early biochemical events after MHC class II-mediated signaling on human B lymphocytes" J Immunol 145(7):2070-2076 (1990).
Brick-Ghannam, C et al., "Protein kinase C (PKC) activation via human leucocyte antigen class II molecules. A novel regulation of PKC activity" J Biol Chem 266(35):24169-24175 (1991).
Ostrand-Rosenberg, S et al., "Abrogation of tumorigenicity by MHC class II antigen expression requires the cytoplasmic domain of the class II molecule" J Immunol 147(7):2419-2422 (1991).
Vaesen, M et al., "Purification and Characterization of Two Putative HLA Class II Associated Proteins: PHAPI and PHAPII" Biol. Chem. Hoppe-Seyler 375:113-126 (1994) (Accession G403007).
Ptashne, M., "How eukaryotic transcriptional activators work" Nature 335(6192):683-689 (1988).
Li, M et al., "Molecular Identification of I.sub.1 .sup.PP2A, a Novel Potent Heat-Stable Inhibitor Protein of Protein Phosphatase 2A" Biochemistry 35:6998-7002 (1996).
Cohen, P., "The structure and regulation of protein phosphatases" Annu Rev Biochem 58:453-508 (1989).
Mumby, MC and Walter, G., "Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth" Physiol Rev 73:673-699 (1993).
Vaesen, M et al., (Direct Submission), GenBank Sequence Database (Accession G1498225), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894 (1996).
Amick, GD et al., "Protein phosphatase 2 is a specific protamine-kinase-inactivating phosphatase" Biochem J 287(Pt3):1019-1022 (1992).
Deibler, GE et al., "Proteolytic activity associated with purified myelin basic protein" Prog Clin Biol Res 146:249-256 (1984).
Li, M et al., "Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney" Biochemistry 34(6):1988-1996 (1995).
Mencinger, M et al., (Direct Submission), GenBank Sequence Database (Accession G1552326), National Center for Biotechnology Information, National Library of Medicine, Bethesda, Maryland 20894 (1997).
Ssanderson, F et al., "Accumulation of HLA-DM, a Regulator of Antigen Presentation, in MHC Class II Compartments" Science 266:1566-1569 (1994).
GenBank entry U70439, Dec. 1996.
GenBank entry Y07969, Oct. 1996.
GenBank entry Y07569, Sep. 1996.
M. Vaesen et al., "Purification and Characterization of Two Putative HLA Class II Associated Proteins: PHAPI and PHAPII", Biol. Chem. Hoppe-Seyler 375: 113-126, Jan. 1994.
GenBank entry T51078, Feb. 1995.
GenBank entry T94833, Mar. 1995.
GenBank entry T94834, Mar. 1995.
GenBank entry R39928, May 1995.

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