Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-04-10
1995-12-05
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514456, 5142335, 514320, 514253, 514408, A61K 3154, A01N 4336
Patent
active
054729777
ABSTRACT:
The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid disease and endometriosis in women comprising administering to a human/woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, halo, or trifluoromethyl;
R.sup.1 and R.sup.2 each are the same or different C.sub.1 -C.sub.6 alkyl group;
n is an integer from 2 to 6; and
R.sup.3 and R.sup.4 each are independently C.sub.1 -C.sub.4 alkyl, or combine to form a substituent selected from the group consisting of pyrrolidino, morpholino, piperidino, piperazino, 4-(C.sub.1 -C.sub.6 alkyl)piperazino, and 4-phenyl-piperazino; or a pharmaceutically acceptable salt thereof.
REFERENCES:
patent: 3340276 (1967-09-01), Carney et al.
patent: 3882287 (1974-07-01), Bolger et al.
U.S. patent application 08/148,786, filed Nov. 1993.
U.S. patent application 08/148,038, filed Nov. 1993.
Bryant Henry U.
Dodge Jeffrey A.
Boone David E.
Eli Lilly and Company
Fontana Steven A.
Henley III Raymond
MacMillan Keith
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