Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1992-12-24
1995-12-05
Allen, Marianne P.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
536 235, 435 691, 4352523, 4352551, 4353201, C12N 1500, C12N 1512, C12N 100, C12N 500
Patent
active
054728665
ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a mammalian 5-HT.sub.4A receptor and an isolated nucleic acid molecule encoding a human 5-HT.sub.4A receptor, an isolated protein which is a mammalian 5-HT.sub.4A receptor, an isolated protein which is a human 5-HT.sub.4A receptor, vectors comprising an isolated nucleic acid molecule encoding a mammalian 5-HT.sub.4A receptor, vectors comprising an isolated nucleic acid molecule encoding a human 5-HT.sub.4A receptor, mammalian cells comprising such vectors, antibodies directed to the 5-HT.sub.4A receptor, nucleic acid probes useful for detecting nucleic acid encoding a mammalian or human 5-HT.sub.4A receptor, antisense oligonucleotides complementary to any sequences of a nucleic acid molecule which encodes a mammalian or human 5-HT.sub.4A receptor, pharmaceutical compounds related to the human 5-HT.sub.4A receptor, and nonhuman transgenic animals which express DNA encoding a normal or a mutant mammalian or human 5-HT.sub.4A receptor. This invention further provides methods for determining ligand binding, detecting expression, drug screening, and treatments for alleviating abnormalities associated with a human 5-HT.sub.4A receptor.
REFERENCES:
patent: 4985352 (1991-01-01), Julius et al.
patent: 5242822 (1993-07-01), Marullo et al.
Loric, S., FEBS Letters, 312 (2-3):203-207, 1992.
Weinshank, R. L., "Molecular Analysis of Serotonin Receptor Subtypes" in Serotonin Receptor Subtypes: Pharmacological Significance and Clinical Implications, Langer et al. (ed.), Int. Acad. Biomed. Drug Res., Basel, Karger, 1992, vol. 1, pp. 1-12.
Branchek Theresa A.
Gerald Christophe
Hartig Paul R.
Weinshank Richard L.
Allen Marianne P.
Synaptic Pharmaceutical Corporation
White John P.
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