Enzymatic process for cephalosporins

Details Enzymatic process for cephalosporins Enzymatic process for cephalosporins

1993-06-18

1995-12-05

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-5-aza-bicyclo

435 43, 435183, 435911, C12P 3500

Patent

active

054728533

ABSTRACT:
N-Terminal .beta.,.gamma.-didehydrovaline di- and tri-peptides are reacted with isopenicillin N synthetase to form 3-exomethylenecepham-4-carboxylic acids, e.g., .delta.-(L-.alpha.-aminoadipoyl)-L-cysteinyl-D-.beta.,.gamma.-didehydroval ine is incubated with the purified enzyme to provide 7.beta.-(L-.alpha.-aminoadipoylamino)-3-exomethylenecepham-4-carboxylic acid. The 3-exocepham products are useful intermediates to 3-alkoxy-3-cephem and the 3-halo-3-cephem antibiotics.

REFERENCES:
ATCC Catalogue of Fungi, 1991, p. 5.
Luengo et al., Biotechnology, vol. 4, pp. 44-47, 1986.
Baldwin, S. Chem Soc. Chem. Comm. (17), 1984, pp. 1167-1170.
Baldwin et al., Tetrahedron, vol. 38, pp. 2773-2776, 1982.

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