Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1981-08-20
1983-02-22
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548190, 548193, 548195, 548199, 548194, 548343, C07D41704, A61K 31425
Patent
active
043748430
ABSTRACT:
A series of 2-guanidino-4-heteroarylthiazoles, wherein the heteroaryl substituent is selected from thiazolyl, triazolyl, imidazolyl, and 2-alkyl, 2-amino and 2-carboxamido derivatives thereof, are disclosed. The novel compounds have activity as antisecretory agents and histamine H.sub.2 antagonists and are useful for the treatment of gastric hyperacidity and peptic ulcers. Also disclosed are pharmaceutical compositions containing the novel compounds of this invention and a method of using the compounds in the treatment of gastric hyperacidity and peptic ulcers. Novel intermediates useful in the preparation of the novel antisecretory compounds are also described.
REFERENCES:
patent: 3519637 (1970-07-01), Hoffer
patent: 3950353 (1976-04-01), Durant
patent: 4220654 (1980-09-01), Bolhoper
patent: 4262126 (1981-04-01), Gilman
patent: 4342765 (1982-08-01), Jones
La Mattina John L.
Lipinski Christopher A.
Blackwood Robert K.
Frost Albert E.
Gerstl Robert
Knuth Charles J.
Pfizer Inc.
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