Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1980-11-24
1983-02-22
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
546261, 546275, 546276, 546277, 546278, 546279, 546280, A61K 3144, C07D41312, C07D41712, C07D40112
Patent
active
043748392
ABSTRACT:
The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N', N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis[N'-(2-(3-methoxy-2-pyridylmethylthio)ethyl)guanidino]propane and 1-[N-(2-(3-methoxy-pyridylmethylthio)ethyl)guanidino]-3-[N'-2-(5-methyl-4- imidazolylmethylthio)ethyl)guanidino]propane. The compounds of this invention are inhibitors of H-2 histamine receptors.
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patent: 4013678 (1977-03-01), Brown et al.
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patent: 4083983 (1978-04-01), Durant et al.
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Durant Graham J.
Ganellin Charon R.
Sach George S.
Foggio Richard D.
Keps Joan S.
Lourie Alan D.
Rotman Alan L.
SmithKline & French Laboratories Limited
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