DNA sequences encoding a brain sodium channel protein

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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4353201, 435 691, 530350, C12N 1512, C12N 1563, G07K 14705

Patent

active

058920188

ABSTRACT:
The present invention discloses a novel subfamily of amiloride sensitive sodium channel proteins isolated and purified from the human central nervous system. DNA sequences encoding such proteins are disclosed as are methods and procedures for development of pharmacologic agents for treatment of diseases associated with central nervous system dysfunction.

REFERENCES:
Waldmann, et al. J. Biol. Chem. vol. 271(18): pp. 10433-10436, May 1996.
Price et al. J. Biol. Chem. vol. 271(14): pp. 7879-7882, Apr. 1996.
Kriegler, M. in Gene Transfer and Expression: A Laboratory Manual, pp. 3-176, Stockton Press, NY, New York, 1990.

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