Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai
Patent
1995-04-18
1999-04-06
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
9,10-seco- cyclopentanohydrophenanthrene ring system doai
514167, A61K 31595, A61K 3159
Patent
active
058918663
ABSTRACT:
A method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D.sub.3 analog, as well as a method of inducing loss of cell proliferation in solid tumors utilizing trans retinoic acid and a Vitamin D.sub.3 analog.
In another aspect, a method of inducing inhibition or loss of cell proliferation in solid tumors utilizing a Vitamin D.sub.3 metabolite, as well as a method of inducing loss of cell proliferation in solid tumors utilizing trans retinoic acid and a Vitamin D.sub.3 metabolite.
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Farach-Carson et al. Nongenomic Actions of 1,25-Dihydroxy D.sub.3 in Rat Osteosarcoma Cells: Structure Function Studies Using Ligand Analogs*:Endocrinology, vol. 129, No. 4, pp. 1876-1884 (1991).
Zhou et al. Development of a Novel 1,25(OH).sub.2 -Vitamin D.sub.3 Analog With Potent Ability to Induce HL-60 Cell Differentiation Without Modulating Calcium metabolism: Blood, vol. 78, No. 1, pp. 75082, Jul. 1, 1991.
Koga et al., J. Steroid. Biochem. Molec. Biol., vol. 39, No. 4A, pp. 455-460, 1991.
Dore Benoit Thomas
Momparler Richard Lewis
Uskokovic Milan Radoje
Goldberg Jerome D.
Hoffman-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
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